ACIST Diastolic Pressure Ratio (dPR)
Non-hyperemic index for coronary physiology
ACIST dPR is not approved in all markets
ACIST Diastolic Pressure Ratio (dPR)
Non-hyperemic index for coronary physiology
ACIST diastolic pressure ratio (dPR), using the ACIST RXi® Rapid Exchange System and Navvus® II MicroCatheter, provides a non-hyperemic alternative for physiological assessment of coronary disease.
Reducing costs, time and patient discomfort
Non-hyperemic pressure ratios, such as dPR, may reduce patient discomfort*, cost** and procedural time.***
Reduced Patient Discomfort
Reduced Cost
Reduced Time
ACIST dPR algorithm
ACIST dPR by the numbers
(compare to iFRcalc)1
0.89
dPR cutpoint
0.999
AUC
98.3%
Sensitivity
99.2%
Specificity
98.3%
PPV
99.2%
NPV
Analysis of the ACIST FFR Study1
Purpose
Methods
Key points
- ACIST dPR is highly correlated with iFRcalc
- ACIST dPR provides similar diagnostic accuracy as iFRcalc
Results
Diagnostic accuracy of dPR (cutpoint of 0.89) referenced to iFRcalc (0.89) was 98.88%
References
* Reduced side effect profile when comparing resting approach (iFR, dPR, Pd/Pa) to FFR with adenosine induced hyperemia
** Cost savings based on the reduced cost of utilizing a resting approach compared to conventional FFR and respective cost of admInistration of hyperemic agent (adenosine)
*** When comparing resting index (iFR, dPR, Pd/Pa) to FFR with adenosine induced hyperemia
1. Data on file TR-07879
2. Sen S, Escaned J, Malik IS, et at. Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardbl. 2012:59(15)1392-1402. doi:10.1016/j.jacc.2011.11.003.
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