ACIST diastolic pressure ratio (dPR), using the ACIST RXi® Rapid Exchange and Navvus® MicroCatheter, provides a non-hyperemic alternative for physiological assessment of coronary disease.

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Reducing costs, time and patient discomfort

Non-hyperemic pressure ratios, such as dPR, may reduce patient discomfort*, cost** and procedural time.***

Reduced Patient Discomfort

Reduced Cost

Reduced Time

ACIST dPR algorithm

ACIST dPR is the ratio of Pd to Pa at the peak-to-peak midpoint, averaged over 5 consecutive heartbeats. ACIST dPR does not rely on an ECG signal to make the calculation.

 

BeatCheckTM is a signal quality monitoring algorithm to identify ectopic rhythms in the hemodynamic waveform (i.e. premature ventricular contractions and arrhythmias).

ACIST dPR by the numbers (compare to iFRcalc)1

0.89

dPR cutpoint

0.999

AUC

98.3%

Sensitivity

99.2%

Specificity

98.3%

PPV

99.2%

NPV

Analysis of the ACIST FFR Study1

Purpose

The data collected during the ACIST-FFR clinical study was retrospectively assessed by an independent, physiologic core laboratory to support ACIST’s dPR algorithm on the ACIST RXi system.

Methods

The dPR value was calculated by the application of ACIST’s fully automated off-line dPR software algorithm. iFRcalc was calculated off-line, by the same core lab, based on the original description of its derivation to determine a final value for iFR.2

Key points

  • ACIST dPR is highly correlated with iFRcalc
  • ACIST dPR provides similar diagnostic accuracy as iFRcalc

Results
Diagnostic accuracy of dPR (cutpoint of 0.89) referenced to iFRcalc (0.89) was 98.88%